|Application ||WB, E|
|Other Accession||NP_005466, 10019|
|Calculated MW||63225 Da|
|Other Names||SH2B adapter protein 3, Lymphocyte adapter protein, Lymphocyte-specific adapter protein Lnk, Signal transduction protein Lnk, SH2B3, LNK|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-LNK / SH2B3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.|
|Tissue Location||Preferentially expressed by lymphoid cell lines|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.
Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis. Hinks A, et al. Ann Rheum Dis, 2010 Jul 20. PMID 20647273.
[Association of the polymorphisms of the ERBB3 and SH2B3 genes with type 1 diabetes] Nikitin AG, et al. Mol Biol (Mosk), 2010 Mar-Apr. PMID 20586186.
Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection. Zhernakova A, et al. Am J Hum Genet, 2010 Jun 11. PMID 20560212.
The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients. Lavrikova EY, et al. Pediatr Diabetes, 2010 Jun 7. PMID 20546165.
The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis. Alcina A, et al. Genes Immun, 2010 Jul. PMID 20508602.
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