|Application ||WB, E|
|Other Accession||NP_002325, 4038, 228357 (mouse), 83469 (rat)|
|Predicted||Mouse, Rat, Cow|
|Calculated MW||212045 Da|
|Other Names||Low-density lipoprotein receptor-related protein 4, LRP-4, Multiple epidermal growth factor-like domains 7, LRP4, KIAA0816, LRP10, MEGF7|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-LRP4 / LRP10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0816, LRP10, MEGF7|
|Function||Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome.
Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women. Liu JM, et al. J Clin Endocrinol Metab, 2010 Sep. PMID 20554715.
LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome. Li Y, et al. Am J Hum Genet, 2010 May 14. PMID 20381006.
Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family. Jeong YH, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 20005200.
New sequence variants associated with bone mineral density. Styrkarsdottir U, et al. Nat Genet, 2009 Jan. PMID 19079262.
Human chromosome 11 DNA sequence and analysis including novel gene identification. Taylor TD, et al. Nature, 2006 Mar 23. PMID 16554811.
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