|Application ||WB, E|
|Other Accession||NP_002363, 4124|
|Calculated MW||131141 Da|
|Other Names||Alpha-mannosidase 2, 220.127.116.11, Golgi alpha-mannosidase II, AMan II, Man II, Mannosidase alpha class 2A member 1, Mannosyl-oligosaccharide 1, 3-1, 6-alpha-mannosidase, MAN2A1, MANA2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-MAN2A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.
Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: a case-control study and meta-analysis. Zhou JB, et al. Med Sci Monit, 2010 Jun. PMID 20512086.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Genome-wide association study of childhood acute lymphoblastic leukemia in Korea. Han S, et al. Leuk Res, 2010 Oct. PMID 20189245.
Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. Miyagawa H, et al. Rheumatology (Oxford), 2008 Feb. PMID 18174230.
Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. Yang Q, et al. BMC Med Genet, 2007 Sep 19. PMID 17903294.
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