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Goat Anti-Melanocortin 3 Receptor Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Melanocortin 3 Receptor Antibody AF1666a
    AF1666a (1 µg/ml) staining of Human Brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P41968
Other Accession NP_063941, 4159
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 36043 Da
Additional Information
Gene ID 4159
Other Names Melanocortin receptor 3, MC3-R, MC3R
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Melanocortin 3 Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MC3R
Function Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Brain, placental, and gut tissues.
Research Areas
Citations (0)

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This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans.


Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Rua帽o G, et al. Pharmacogenomics, 2010 Jul. PMID 20602615.
Identification of Three Novel Genetic Variants in the Melanocortin-3 Receptor of Obese Children. Zegers D, et al. Obesity (Silver Spring), 2010 Jun 10. PMID 20539302.
Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064.
Melanocortin-3 receptor gene variants: association with childhood obesity and eating behavior in Chilean families. Obreg贸n AM, et al. Nutrition, 2010 Jul-Aug. PMID 20144537.
Novel binding motif of ACTH analogues at the melanocortin receptors. Yang Y, et al. Biochemistry, 2009 Oct 20. PMID 19743876.

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$ 325.00
Cat# AF1666a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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