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Goat Anti-MELK Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-MELK Antibody AF1668a
    AF1668a (0.1 µg/ml) staining of human testis lysate (RIPA buffer, 1.4E5 cells per lane). Detected by western blot using chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14680
Other Accession NP_055606, 9833
Reactivity Human
Predicted Mouse, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 74642 Da
Additional Information
Gene ID 9833
Other Names Maternal embryonic leucine zipper kinase, hMELK,, Protein kinase Eg3, pEg3 kinase, Protein kinase PK38, hPK38, Tyrosine-protein kinase MELK,, MELK, KIAA0175
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-MELK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0175
Function Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
Cellular Location Cell membrane; Peripheral membrane protein
Tissue Location Expressed in placenta, kidney, thymus, testis, ovary and intestine.
Research Areas
Citations (0)

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Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer. Pickard MR, et al. Breast Cancer Res, 2009. PMID 19671159.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas. Marie SK, et al. Int J Cancer, 2008 Feb 15. PMID 17960622.
Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. Nakano I, et al. J Neurosci Res, 2008 Jan. PMID 17722061.
Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. Lin ML, et al. Breast Cancer Res, 2007. PMID 17280616.

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$ 325.00
Cat# AF1668a
(40 western blots)
Availability: 7-10 days
Bulk Size
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