|Application ||WB, E|
|Other Accession||NP_001008229, 4340|
|Predicted||Mouse, Rat, Pig, Cow|
|Calculated MW||28193 Da|
|Other Names||Myelin-oligodendrocyte glycoprotein, MOG|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-MOG Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication.|
|Cellular Location||Isoform 1: Cell membrane; Multi-pass membrane protein Isoform 2: Cell membrane; Single-pass type I membrane protein Isoform 4: Cell membrane; Single-pass type I membrane protein Isoform 7: Cell membrane; Single-pass type I membrane protein Isoform 9: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. Cree BA, et al. PLoS One, 2010 Jun 25. PMID 20593013. Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 May 14. PMID 20471030. The association of myelin oligodendrocyte glycoprotein gene and white matter volume in obsessive-compulsive disorder. Atmaca M, et al. J Affect Disord, 2010 Aug. PMID 20452030. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
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