|Application ||WB, IHC, E|
|Other Accession||NP_001018881, 10057, 27416 (mouse), 116721 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||160660 Da|
|Other Names||Multidrug resistance-associated protein 5, ATP-binding cassette sub-family C member 5, Multi-specific organic anion transporter C, MOAT-C, SMRP, pABC11, ABCC5, MRP5|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-MRP5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a multispecific organic anion pump which can transport nucleotide analogs.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||All isoforms are equally expressed in retina.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Inhibition of tetramethylpyrazine on P-gp, MRP2, MRP3 and MRP5 in multidrug resistant human hepatocellular carcinoma cells. Wang XB, et al. Oncol Rep, 2010 Jan. PMID 19956884.
Human skeletal muscle drug transporters determine local exposure and toxicity of statins. Knauer MJ, et al. Circ Res, 2010 Feb 5. PMID 19940267.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Dependence of multidrug resistance protein-mediated cyclic nucleotide efflux on the background sodium conductance. Kucka M, et al. Mol Pharmacol, 2010 Feb. PMID 19903828.
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