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Goat Anti-MTHFS Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-MTHFS Antibody AF1691a
    AF1691a (0.5 µg/ml) staining of Human Liver lysate (35 µg protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49914
Other Accession NP_006432, 10588
Reactivity Human
Predicted Mouse
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 23256 Da
Additional Information
Gene ID 10588
Other Names 5-formyltetrahydrofolate cyclo-ligase,, 5, 10-methenyl-tetrahydrofolate synthetase, MTHFS, Methenyl-THF synthetase, MTHFS
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-MTHFS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium. Kelemen LE, et al. Cancer Epidemiol Biomarkers Prev, 2010 Jul. PMID 20570913.
Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer. Hazra A, et al. Cancer Causes Control, 2010 Mar. PMID 19936946.
Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues. Wu D, et al. Cancer Res, 2009 Sep 15. PMID 19738041.
An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). Franke B, et al. Birth Defects Res A Clin Mol Teratol, 2009 Mar. PMID 19161160.

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$ 325.00
Cat# AF1691a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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