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Goat Anti-MTNR1A Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-MTNR1A Antibody AF1693a
    AF1693a (0.3 µg/ml) staining of KELLY lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P48039
Other Accession NP_005949, 4543
Reactivity Human
Predicted Mouse, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 39375 Da
Additional Information
Gene ID 4543
Other Names Melatonin receptor type 1A, Mel-1A-R, Mel1a receptor, MTNR1A
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-MTNR1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus
Research Areas
Citations (0)

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This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.


Analysis of genetic variations in the human melatonin receptor (MTNR1A, MTNR1B) genes and antipsychotics-induced tardive dyskinesia in schizophrenia. Lai IC, et al. World J Biol Psychiatry, 2010 Aug 23. PMID 20726823.
Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population. Chaste P, et al. PLoS One, 2010 Jul 15. PMID 20657642.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Mutation screening of melatonin-related genes in patients with autism spectrum disorders. Jonsson L, et al. BMC Med Genomics, 2010 Apr 8. PMID 20377855.
Melatonin MT1 and MT2 receptor expression in Parkinson's disease. Adi N, et al. Med Sci Monit, 2010 Feb. PMID 20110911.

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$ 325.00
Cat# AF1693a
(40 western blots)
Availability: 7-10 days
Bulk Size
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