|Application ||WB, IHC, E|
|Other Accession||NP_000245, 4548, 81522 (rat)|
|Predicted||Mouse, Rat, Pig, Dog|
|Calculated MW||140527 Da|
|Other Names||Methionine synthase, 220.127.116.11, 5-methyltetrahydrofolate--homocysteine methyltransferase, Vitamin-B12 dependent methionine synthase, MS, MTR|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-MTR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).|
|Tissue Location||Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta Expressed at lower levels in lung, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G.
Genetic variants in one-carbon metabolism-related genes contribute to NSCLC prognosis in a Chinese population. Jin G, et al. Cancer, 2010 Aug 24. PMID 20737570.
Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism. Porter KE, et al. Environ Res, 2010 Aug. PMID 20670920.
Associations of various gene polymorphisms with toxicity in colorectal cancer patients receiving oral uracil and tegafur plus leucovorin: a prospective study. Tsunoda A, et al. Ann Oncol, 2010 Jul 19. PMID 20647221.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
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