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Goat Anti-MTR Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-MTR Antibody AF1694a
    AF1694a (2 µg/ml) staining of Hela lysate (RIPA buffer, 1.4E5 cells per lane). Detected by western blot using chemiluminescence.
  • IHC - Goat Anti-MTR Antibody AF1694a
    AF1694a (3.8 µg/ml) staining of paraffin embedded Human Adrenal Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99707
Other Accession NP_000245, 4548, 81522 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 140527 Da
Additional Information
Gene ID 4548
Other Names Methionine synthase,, 5-methyltetrahydrofolate--homocysteine methyltransferase, Vitamin-B12 dependent methionine synthase, MS, MTR
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-MTR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MTR
Function Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
Cellular Location Cytoplasm.
Tissue Location Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta Expressed at lower levels in lung, liver and kidney
Research Areas
Citations (0)

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MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G.


Genetic variants in one-carbon metabolism-related genes contribute to NSCLC prognosis in a Chinese population. Jin G, et al. Cancer, 2010 Aug 24. PMID 20737570.
Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism. Porter KE, et al. Environ Res, 2010 Aug. PMID 20670920.
Associations of various gene polymorphisms with toxicity in colorectal cancer patients receiving oral uracil and tegafur plus leucovorin: a prospective study. Tsunoda A, et al. Ann Oncol, 2010 Jul 19. PMID 20647221.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.

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$ 325.00
Cat# AF1694a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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