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Goat Anti-Munc13-4 / UNC13D (C terminus) Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Munc13-4 / UNC13D (C terminus) Antibody AF1695a
    AF1695a (2 µg/ml) staining of Human T-lymphocyte lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Data provided by anonymous customer.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q70J99
Other Accession NP_954712, 201294
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 123282 Da
Additional Information
Gene ID 201294
Other Names Protein unc-13 homolog D, Munc13-4, UNC13D
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Munc13-4 / UNC13D (C terminus) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UNC13D
Function Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Late endosome. Recycling endosome. Lysosome Note=Colocalizes with cytotoxic granules at the plasma membrane Localizes to endosomal exocytic vesicles
Tissue Location Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells
Research Areas
Citations (0)

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This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.


UNC13D is the predominant causative gene with recurrent splicing mutations in Korean patients with familial hemophagocytic lymphohistiocytosis. Yoon HS, et al. Haematologica, 2010 Apr. PMID 20015888.
Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity. Wood SM, et al. Blood, 2009 Nov 5. PMID 19704116.
Neonatal primary hemophagocytic lymphohistiocytosis in Turkish children. Gurgey A, et al. J Pediatr Hematol Oncol, 2008 Dec. PMID 19131769.
Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases. Beutler B. Immunol Rev, 2009 Jan. PMID 19120489.
Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms. Zhang K, et al. Arthritis Rheum, 2008 Sep. PMID 18759271.

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$ 325.00
Cat# AF1695a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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