|Application ||WB, E|
|Other Accession||NP_690869, 121441|
|Calculated MW||71966 Da|
|Other Names||Protein NEDD1, Neural precursor cell expressed developmentally down-regulated protein 1, NEDD-1, NEDD1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-NEDD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome|
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Provided below are standard protocols that you may find useful for product applications.
The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. Crawford NP, et al. J Biol Chem, 2009 Oct 16. PMID 19710015.
Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. Zhang X, et al. J Cell Sci, 2009 Jul 1. PMID 19509060.
The centrosome protein NEDD1 as a potential pharmacological target to induce cell cycle arrest. Tillement V, et al. Mol Cancer, 2009 Feb 25. PMID 19243593.
FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. Zhu H, et al. J Cell Biol, 2008 Dec 1. PMID 19029337.
The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. Petretti C, et al. EMBO Rep, 2006 Apr. PMID 16462731.
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