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Goat Anti-NEDD9 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-NEDD9 Antibody AF1715a
    AF1715a (0.1 µg/ml) staining of Human Kidney lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14511
Other Accession NP_892011, 4739, 18003 (mouse), 291044 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 92861 Da
Additional Information
Gene ID 4739
Other Names Enhancer of filamentation 1, hEF1, CRK-associated substrate-related protein, CAS-L, CasL, Cas scaffolding protein family member 2, Neural precursor cell expressed developmentally down-regulated protein 9, NEDD-9, Renal carcinoma antigen NY-REN-12, p105, Enhancer of filamentation 1 p55, NEDD9, CASL, CASS2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-NEDD9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEDD9
Synonyms CASL, CASS2
Function Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.
Cellular Location Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm. Cell junction, focal adhesion. Note=Localizes to both the cell nucleus and the cell periphery and is differently localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle
Tissue Location Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues
Research Areas
Citations (0)

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Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Corneveaux JJ, et al. Hum Mol Genet, 2010 Aug 15. PMID 20534741.
Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent. Lucas JT Jr, et al. Oncogene, 2010 Aug 5. PMID 20498643.
Different implication of NEDD9 genetic variant in early and late-onset Alzheimer's disease. Tedde A, et al. Neurosci Lett, 2010 Jun 25. PMID 20430066.
A novel large regulator RNA, B2, partially overlaps the HEF1/NEDD9/Cas-L gene. Malleter M, et al. Int J Mol Med, 2010 Jun. PMID 20428794.
Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. Laumet G, et al. J Alzheimers Dis, 2010. PMID 20413850.

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$ 325.00
Cat# AF1715a
(40 western blots)
Availability: 7-10 days
Bulk Size
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