|Application ||WB, E|
|Other Accession||NP_892011, 4739, 18003 (mouse), 291044 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||92861 Da|
|Other Names||Enhancer of filamentation 1, hEF1, CRK-associated substrate-related protein, CAS-L, CasL, Cas scaffolding protein family member 2, Neural precursor cell expressed developmentally down-regulated protein 9, NEDD-9, Renal carcinoma antigen NY-REN-12, p105, Enhancer of filamentation 1 p55, NEDD9, CASL, CASS2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-NEDD9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.|
|Cellular Location||Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm. Cell junction, focal adhesion. Note=Localizes to both the cell nucleus and the cell periphery and is differently localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle|
|Tissue Location||Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Corneveaux JJ, et al. Hum Mol Genet, 2010 Aug 15. PMID 20534741.
Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent. Lucas JT Jr, et al. Oncogene, 2010 Aug 5. PMID 20498643.
Different implication of NEDD9 genetic variant in early and late-onset Alzheimer's disease. Tedde A, et al. Neurosci Lett, 2010 Jun 25. PMID 20430066.
A novel large regulator RNA, B2, partially overlaps the HEF1/NEDD9/Cas-L gene. Malleter M, et al. Int J Mol Med, 2010 Jun. PMID 20428794.
Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. Laumet G, et al. J Alzheimers Dis, 2010. PMID 20413850.
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