|Application ||WB, E|
|Other Accession||NP_004813, 9423, 18208 (mouse), 114523 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||67748 Da|
|Other Names||Netrin-1, Epididymis tissue protein Li 131P, NTN1, NTN1L|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Netrin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas Expressed in epididymis (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.
Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells. Dumartin L, et al. Gastroenterology, 2010 Apr. PMID 20080097.
Netrin-1 dampens pulmonary inflammation during acute lung injury. Mirakaj V, et al. Am J Respir Crit Care Med, 2010 Apr 15. PMID 20075388.
Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters. Sokolowski M, et al. Mol Psychiatry, 2010 Jan. PMID 20029409.
Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery. Ramesh G, et al. Clin J Am Soc Nephrol, 2010 Mar. PMID 20007677.
Functional implication of Netrin expression in malignant melanoma. Kaufmann S, et al. Cell Oncol, 2009. PMID 19940358.
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