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Goat Anti-Netrin 1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Netrin 1 Antibody AF1718a
    AF1718a (0.5 µg/ml) staining of Rat Brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95631
Other Accession NP_004813, 9423, 18208 (mouse), 114523 (rat)
Reactivity Human, Mouse, Rat
Predicted Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 67748 Da
Additional Information
Gene ID 9423
Other Names Netrin-1, Epididymis tissue protein Li 131P, NTN1, NTN1L
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Netrin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NTN1
Synonyms NTN1L
Function Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas Expressed in epididymis (at protein level)
Research Areas
Citations (0)

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Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.


Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells. Dumartin L, et al. Gastroenterology, 2010 Apr. PMID 20080097.
Netrin-1 dampens pulmonary inflammation during acute lung injury. Mirakaj V, et al. Am J Respir Crit Care Med, 2010 Apr 15. PMID 20075388.
Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters. Sokolowski M, et al. Mol Psychiatry, 2010 Jan. PMID 20029409.
Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery. Ramesh G, et al. Clin J Am Soc Nephrol, 2010 Mar. PMID 20007677.
Functional implication of Netrin expression in malignant melanoma. Kaufmann S, et al. Cell Oncol, 2009. PMID 19940358.

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$ 325.00
Cat# AF1718a
(40 western blots)
Availability: 7-10 days
Bulk Size
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