|Application ||WB, E|
|Other Accession||NP_620072, 9378, 18189 (mouse), 60391 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||46861 Da|
|Other Names||Neurexin-1-beta, Neurexin I-beta, NRXN1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Neurexin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Localized on the pre- synaptic membrane.|
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Provided below are standard protocols that you may find useful for product applications.
Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible.
Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. Leone P, et al. EMBO J, 2010 Jul 21. PMID 20543817.
Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. Ching MS, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jun 5. PMID 20468056.
TCF4, schizophrenia, and Pitt-Hopkins Syndrome. Blake DJ, et al. Schizophr Bull, 2010 May. PMID 20421335.
Association between neurexin 1 (NRXN1) polymorphisms and the smoking behavior of elderly Japanese. Sato N, et al. Psychiatr Genet, 2010 Jun. PMID 20414139.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
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