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Goat Anti-Neurexin 1 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P58400 |
| Other Accession | NP_620072, 9378, 18189 (mouse), 60391 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 50424 Da |
| Gene ID | 9378 |
|---|---|
| Other Names | Neurexin-1-beta, Neurexin I-beta, NRXN1 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-Neurexin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NRXN1 (HGNC:8008) |
|---|---|
| Function | Neuronal cell surface protein involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. Plays a role in formation of synaptic junctions. |
| Cellular Location | Presynaptic cell membrane {ECO:0000250|UniProtKB:Q63373}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q63373} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible.
References
Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. Leone P, et al. EMBO J, 2010 Jul 21. PMID 20543817.
Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. Ching MS, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jun 5. PMID 20468056.
TCF4, schizophrenia, and Pitt-Hopkins Syndrome. Blake DJ, et al. Schizophr Bull, 2010 May. PMID 20421335.
Association between neurexin 1 (NRXN1) polymorphisms and the smoking behavior of elderly Japanese. Sato N, et al. Psychiatr Genet, 2010 Jun. PMID 20414139.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
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