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Goat Anti-Neurexin 1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Neurexin 1 Antibody AF1720a
    HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human NRXN1 with DYKDDDDK tag probed with AF1720a(0.5ug/ml) in Lane A and probed with anti- DYKDDDDK Tag (1/3000) in lane C. Mock-transfected HEK293 probed with AF1720a(1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P58400
Other Accession NP_620072, 9378, 18189 (mouse), 60391 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 46861 Da
Additional Information
Gene ID 9378
Other Names Neurexin-1-beta, Neurexin I-beta, NRXN1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Neurexin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NRXN1
Function Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Localized on the pre- synaptic membrane.
Research Areas
Citations (0)

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Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible.


Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. Leone P, et al. EMBO J, 2010 Jul 21. PMID 20543817.
Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. Ching MS, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jun 5. PMID 20468056.
TCF4, schizophrenia, and Pitt-Hopkins Syndrome. Blake DJ, et al. Schizophr Bull, 2010 May. PMID 20421335.
Association between neurexin 1 (NRXN1) polymorphisms and the smoking behavior of elderly Japanese. Sato N, et al. Psychiatr Genet, 2010 Jun. PMID 20414139.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.

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$ 325.00
Cat# AF1720a
(40 western blots)
Availability: 7-10 days
Bulk Size
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