|Application ||WB, E|
|Other Accession||NP_006170, 4909|
|Calculated MW||22427 Da|
|Other Names||Neurotrophin-4, NT-4, Neurotrophin-5, NT-5, Neutrophic factor 4, NTF4, NTF5|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Neurotrophin 5 / NT4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Target-derived survival factor for peripheral sensory sympathetic neurons.|
|Tissue Location||Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood.
Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population. Vithana EN, et al. Mol Vis, 2010 Aug 15. PMID 20806036.
Variations in NTF4, VAV2 and VAV3 Genes Are Not Involved With Primary Open Angle and Primary Angle Closure Glaucomas in an Indian Population. Rao KN, et al. Invest Ophthalmol Vis Sci, 2010 May 12. PMID 20463313.
Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. Gratac貌s M, et al. J Psychiatr Res, 2010 Oct. PMID 20219210.
No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma. Liu Y, et al. Am J Hum Genet, 2010 Mar 12. PMID 20215012.
Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development. Childs AJ, et al. Dev Dyn, 2010 Apr. PMID 20175187.
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