|Application ||WB, IHC, E|
|Other Accession||NP_612568, 5511, 100336 (mouse)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||38479 Da|
|Other Names||Nuclear inhibitor of protein phosphatase 1, NIPP-1, Protein phosphatase 1 regulatory inhibitor subunit 8, Activator of RNA decay, 3.1.4.-, ARD-1, PPP1R8, ARD1, NIPP1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-NIPP1 / PPP1R8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.|
|Cellular Location||Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear|
|Tissue Location||Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells|
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