|Application ||IHC, E|
|Other Accession||NP_001159438, 83394|
|Calculated MW||106781 Da|
|Other Names||Membrane-associated phosphatidylinositol transfer protein 3, Phosphatidylinositol transfer protein, membrane-associated 3, PITPnm 3, Pyk2 N-terminal domain-interacting receptor 1, NIR-1, PITPNM3, NIR1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-NIR1 / PITPNM3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions.|
|Cellular Location||Endomembrane system; Peripheral membrane protein|
|Tissue Location||Detected in brain and spleen, and at low levels in ovary.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. The calcium-binding protein has phosphatidylinositol (PI) transfer activity and interacts with the protein tyrosine kinase PTK2B (also known as PYK2). The protein is homologous to a Drosophila protein that is implicated in the visual transduction pathway in flies. Mutations in this gene result in autosomal dominant cone dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
Mutation in the PYK2-binding domain of PITPNM3 causes autosomal dominant cone dystrophy (CORD5) in two Swedish families. K枚hn L, et al. Adv Exp Med Biol, 2008. PMID 18188949.
Mutation in the PYK2-binding domain of PITPNM3 causes autosomal dominant cone dystrophy (CORD5) in two Swedish families. K枚hn L, et al. Eur J Hum Genet, 2007 Jun. PMID 17377520.
Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3. Ocaka L, et al. Cytogenet Genome Res, 2005. PMID 15627748.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Lev S, et al. Mol Cell Biol, 1999 Mar. PMID 10022914.
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