|Application ||WB, IHC, IF, E|
|Other Accession||NP_000611, 4842|
|Predicted||Rat, Dog, Cow|
|Calculated MW||160970 Da|
|Other Names||Nitric oxide synthase, brain, 22.214.171.124, Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1, bNOS, NOS1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-NOS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.|
|Cellular Location||Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).|
|Tissue Location||Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland|
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Provided below are standard protocols that you may find useful for product applications.
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. This gene encodes a nitric oxide synthase which is highly expressed in skeletal muscle. Genetic variations in this gene are associated with infantile hypertrophic pyloric stenosis type 1.
A Gradient of NOS1 Overproduction Alleles in European and Mediterranean Populations. Piras I, et al. Genet Test Mol Biomarkers, 2010 Sep 6. PMID 20818978.
Genetic analysis of nitric oxide synthase 1 variants in schizophrenia and bipolar disorder. Silberberg G, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul 19. PMID 20645313.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
The effects of NOS1 gene on asthma and total IgE levels in Taiwanese children, and the interactions with environmental factors. Wang TN, et al. Pediatr Allergy Immunol, 2010 Jul 1. PMID 20609134.
A putative cis-acting polymorphism in the NOS1 gene is associated with schizophrenia and NOS1 immunoreactivity in the postmortem brain. Cui H, et al. Schizophr Res, 2010 Aug. PMID 20605417.
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