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Goat Anti-NOS1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-NOS1 Antibody AF1739a
    AF1739a (0.1 µg/ml) staining of Human Skeletal Muscle lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P29475
Other Accession NP_000611, 4842
Reactivity Human, Mouse
Predicted Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 160970 Da
Additional Information
Gene ID 4842
Other Names Nitric oxide synthase, brain,, Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1, bNOS, NOS1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-NOS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOS1
Function Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
Cellular Location Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).
Tissue Location Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland
Research Areas
Citations (0)

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Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. This gene encodes a nitric oxide synthase which is highly expressed in skeletal muscle. Genetic variations in this gene are associated with infantile hypertrophic pyloric stenosis type 1.


A Gradient of NOS1 Overproduction Alleles in European and Mediterranean Populations. Piras I, et al. Genet Test Mol Biomarkers, 2010 Sep 6. PMID 20818978.
Genetic analysis of nitric oxide synthase 1 variants in schizophrenia and bipolar disorder. Silberberg G, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul 19. PMID 20645313.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
The effects of NOS1 gene on asthma and total IgE levels in Taiwanese children, and the interactions with environmental factors. Wang TN, et al. Pediatr Allergy Immunol, 2010 Jul 1. PMID 20609134.
A putative cis-acting polymorphism in the NOS1 gene is associated with schizophrenia and NOS1 immunoreactivity in the postmortem brain. Cui H, et al. Schizophr Res, 2010 Aug. PMID 20605417.

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$ 325.00
Cat# AF1739a
(40 western blots)
Availability: 7-10 days
Bulk Size
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