|Application ||WB, IHC, E|
|Other Accession||NP_006482, 4857|
|Calculated MW||52056 Da|
|Other Names||RNA-binding protein Nova-1, Neuro-oncological ventral antigen 1, Onconeural ventral antigen 1, Paraneoplastic Ri antigen, Ventral neuron-specific protein 1, NOVA1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-NOVA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate RNA splicing or metabolism in a specific subset of developing neurons.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.
Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients. Alkelai A, et al. Psychopharmacology (Berl), 2009 Oct. PMID 19680635.
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. Vasan RS, et al. JAMA, 2009 Jul 8. PMID 19584346.
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. Anney RJ, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Dec 5. PMID 18951430.
Paraneoplastic antibody during follow-up of a patient with anti-Ri-associated paraneoplastic neurological syndrome. Stich O, et al. Acta Neurol Scand, 2009 May. PMID 18822086.
Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV. Ratti A, et al. J Biol Chem, 2008 Mar 21. PMID 18218628.
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