|Application ||WB, IP, E|
|Other Accession||NP_032757, 4887, 18167 (mouse), 66024 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||42731 Da|
|Other Names||Neuropeptide Y receptor type 2, NPY2-R, NPY-Y2 receptor, Y2 receptor, NPY2R|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Npy2r (mouse) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
NPY neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice. Shi YC, et al. PLoS One, 2010 Jun 29. PMID 20613867.
New method of manometric measurement of gastroduodenal motility in conscious mice: effects of ghrelin and Y2 depletion. Tanaka R, et al. Am J Physiol Gastrointest Liver Physiol, 2009 Nov. PMID 20501433.
The central and basolateral amygdala are critical sites of neuropeptide Y/Y2 receptor-mediated regulation of anxiety and depression. Tasan RO, et al. J Neurosci, 2010 May 5. PMID 20445054.
NPY Y2 receptor agonist PYY(3-36) inhibits diarrhea by reducing intestinal fluid secretion and slowing colonic transit in mice. Moriya R, et al. Peptides, 2010 Apr. PMID 19925840.
Peripheral peptide YY inhibits propulsive colonic motor function through Y2 receptor in conscious mice. Wang L, et al. Am J Physiol Gastrointest Liver Physiol, 2010 Jan. PMID 19892938.
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