|Application ||WB, E|
|Other Accession||NP_775180, 3164, 15370 (mouse), 79240 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||64463 Da|
|Other Names||Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3, NR4A1, GFRP1, HMR, NAK1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Nur77 / TR3 (isoform a) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GFRP1, HMR, NAK1|
|Function||Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Fetal muscle and adult liver, brain and thyroid|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.
Replicated association of the NR4A3 gene with smoking behavior in schizophrenia and in bipolar disorder. Novak G, et al. Genes Brain Behav, 2010 Jul 24. PMID 20659174.
Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis. Zhao Y, et al. Circ Res, 2010 Aug 20. PMID 20558821.
No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes. M脤ssig K, et al. BMC Med Genet, 2010 Jun 4. PMID 20525362.
Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1. Kang SA, et al. Biochem Pharmacol, 2010 Sep 15. PMID 20438716.
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