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Goat Anti-ORAI1 / CRACM1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-ORAI1 / CRACM1 Antibody AF1754a
    AF1754a (0.03 µg/ml) staining of Human Placenta lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96D31
Other Accession NP_116179, 84876, 109305 (mouse)
Reactivity Human
Predicted Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 32668 Da
Additional Information
Gene ID 84876
Other Names Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A, ORAI1, CRACM1, TMEM142A
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ORAI1 / CRACM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ORAI1
Synonyms CRACM1, TMEM142A
Function Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
Cellular Location Cell membrane; Multi- pass membrane protein Note=Isoform beta is more mobile in the plasma membrane
Research Areas
Citations (0)

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CRACM1 is a plasma membrane protein essential for store-operated calcium entry (Vig et al., 2006 [PubMed 16645049]).


Protein kinase C-induced phosphorylation of Orai1 regulates the intracellular Ca2+ level via the store-operated Ca2+ channel. Kawasaki T, et al. J Biol Chem, 2010 Aug 13. PMID 20534587.
A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells. Motiani RK, et al. J Biol Chem, 2010 Jun 18. PMID 20395295.
Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. Bogeski I, et al. Sci Signal, 2010 Mar 30. PMID 20354224.
Pore architecture of the ORAI1 store-operated calcium channel. Zhou Y, et al. Proc Natl Acad Sci U S A, 2010 Mar 16. PMID 20194792.
Expression and association of TRPC subtypes with Orai1 and STIM1 in human parathyroid. Lu M, et al. J Mol Endocrinol, 2010 May. PMID 20194530.

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$ 325.00
Cat# AF1754a
(40 western blots)
Availability: 7-10 days
Bulk Size
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