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Goat Anti-ORC4L Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-ORC4L Antibody AF1756a
    AF1756a (0.5 µg/ml) staining of Rat Heart lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43929
Other Accession NP_002543, 5000
Reactivity Human, Mouse
Predicted Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 50377 Da
Additional Information
Gene ID 5000
Other Names Origin recognition complex subunit 4, ORC4, ORC4L
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ORC4L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ORC4
Synonyms ORC4L
Function Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene.


Novel ORC4L gene mutation in B-cell lymphoproliferative disorders. Radojkovic M, et al. Am J Med Sci, 2009 Dec. PMID 20010161.
Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. Enjuanes A, et al. Cancer Res, 2008 Dec 15. PMID 19074885.
ATP-dependent assembly of the human origin recognition complex. Siddiqui K, et al. J Biol Chem, 2007 Nov 2. PMID 17716973.
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
Ku80 binds to human replication origins prior to the assembly of the ORC complex. Sibani S, et al. Biochemistry, 2005 May 31. PMID 15910003.

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$ 325.00
Cat# AF1756a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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