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Goat Anti-ORP1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-ORP1 Antibody AF1758a
    AF1758a staining (0.5 µg/ml) of Human Muscle lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BXW6
Other Accession NP_542164, 114876, 64291 (mouse), 259221 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 108470 Da
Additional Information
Gene ID 114876
Other Names Oxysterol-binding protein-related protein 1, ORP-1, OSBP-related protein 1, OSBPL1A, ORP1, OSBP8, OSBPL1, OSBPL1B
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ORP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A.
Cellular Location Late endosome. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes
Research Areas
Citations (0)

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This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.


An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. Hsu YH, et al. PLoS Genet, 2010 Jun 10. PMID 20548944.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning. Rocha N, et al. J Cell Biol, 2009 Jun 29. PMID 19564404.
A genome-wide association study identifies protein quantitative trait loci (pQTLs). Melzer D, et al. PLoS Genet, 2008 May 9. PMID 18464913.
SNP-specific array-based allele-specific expression analysis. Bjornsson HT, et al. Genome Res, 2008 May. PMID 18369178.

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$ 325.00
Cat# AF1758a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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