|Application ||WB, E|
|Other Accession||NP_542164, 114876, 64291 (mouse), 259221 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||108470 Da|
|Other Names||Oxysterol-binding protein-related protein 1, ORP-1, OSBP-related protein 1, OSBPL1A, ORP1, OSBP8, OSBPL1, OSBPL1B|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ORP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ORP1, OSBP8, OSBPL1, OSBPL1B|
|Function||Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).|
|Cellular Location||Late endosome. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. Hsu YH, et al. PLoS Genet, 2010 Jun 10. PMID 20548944.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning. Rocha N, et al. J Cell Biol, 2009 Jun 29. PMID 19564404.
A genome-wide association study identifies protein quantitative trait loci (pQTLs). Melzer D, et al. PLoS Genet, 2008 May 9. PMID 18464913.
SNP-specific array-based allele-specific expression analysis. Bjornsson HT, et al. Genome Res, 2008 May. PMID 18369178.
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