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Goat Anti-OSBP Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-OSBP Antibody AF1762a
    AF1762a (0.1 µg/ml) staining of Human Placenta lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P22059
Other Accession NP_002547, 5007
Reactivity Human
Predicted Mouse, Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 89421 Da
Additional Information
Gene ID 5007
Other Names Oxysterol-binding protein 1, OSBP, OSBP1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-OSBP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms OSBP1
Function Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
Cellular Location Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase


Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Functional implications of sterol transport by the oxysterol-binding protein gene family. Ngo MH, et al. Biochem J, 2010 Jul 1. PMID 20545625.
Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies. Furuita K, et al. J Biol Chem, 2010 Apr 23. PMID 20178991.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Role of oxysterol binding protein in hepatitis C virus infection. Amako Y, et al. J Virol, 2009 Sep. PMID 19570870.

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$ 325.00
Cat# AF1762a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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