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Goat Anti-OX1R and OX2R Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-OX1R and OX2R Antibody AF1768a
    AF1768a (0.5 µg/ml) staining of Frontal Cortex lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O43613
Other Accession NP_001517, 3061, 3062, 230777 (mouse), 25593 (rat)
Reactivity Human, Mouse, Rat
Predicted Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 47536 Da
Additional Information
Gene ID 3061
Other Names Orexin receptor type 1, Ox-1-R, Ox1-R, Ox1R, Hypocretin receptor type 1, HCRTR1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-OX1R and OX2R Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HCRTR1
Function Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).
Cellular Location Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B.

References

Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064.
Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. Saus E, et al. J Psychiatr Res, 2010 Apr 14. PMID 20398908.
Arachidonic acid release mediated by OX1 orexin receptors. Turunen PM, et al. Br J Pharmacol, 2010 Jan. PMID 20002100.
Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis. El Firar A, et al. FASEB J, 2009 Dec. PMID 19661287.
Involvement of TRPC3 channels in calcium oscillations mediated by OX(1) orexin receptors. Peltonen HM, et al. Biochem Biophys Res Commun, 2009 Jul 31. PMID 19464259.

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$ 335.00
Cat# AF1768a
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