|Application ||WB, E|
|Other Accession||NP_001517, 3061, 3062, 230777 (mouse), 25593 (rat)|
|Reactivity||Human, Mouse, Rat|
|Predicted||Pig, Dog, Cow|
|Calculated MW||47536 Da|
|Other Names||Orexin receptor type 1, Ox-1-R, Ox1-R, Ox1R, Hypocretin receptor type 1, HCRTR1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-OX1R and OX2R Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B.
Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064.
Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. Saus E, et al. J Psychiatr Res, 2010 Apr 14. PMID 20398908.
Arachidonic acid release mediated by OX1 orexin receptors. Turunen PM, et al. Br J Pharmacol, 2010 Jan. PMID 20002100.
Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis. El Firar A, et al. FASEB J, 2009 Dec. PMID 19661287.
Involvement of TRPC3 channels in calcium oscillations mediated by OX(1) orexin receptors. Peltonen HM, et al. Biochem Biophys Res Commun, 2009 Jul 31. PMID 19464259.
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