|Application ||WB, IHC, E|
|Other Accession||NP_002553, 5027, 18439 (mouse), 29665 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||68585 Da|
|Other Names||P2X purinoceptor 7, P2X7, ATP receptor, P2Z receptor, Purinergic receptor, P2RX7|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-P2RX7 / P2X7 receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed with highest levels in brain and immune tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
Association of P2X7 receptor +1513 (A-->C) polymorphism with tuberculosis in a Punjabi population. Sharma S, et al. Int J Tuberc Lung Dis, 2010 Sep. PMID 20819262.
Polymorphism in the p2x7 gene increases susceptibility to extrapulmonary tuberculosis in Turkish children. Tekin D, et al. Pediatr Infect Dis J, 2010 Aug. PMID 20661107.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosis. Jamieson SE, et al. Genes Immun, 2010 Jul. PMID 20535134.
Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms. Ward JR, et al. J Biol Chem, 2010 Jul 23. PMID 20495003.
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