|Application ||WB, E|
|Other Accession||NP_002551, 5025, 18438 (mouse), 29659 (rat)|
|Predicted||Rat, Dog, Cow|
|Calculated MW||43369 Da|
|Other Names||P2X purinoceptor 4, P2X4, ATP receptor, Purinergic receptor, P2RX4|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-P2X4 / P2X4R Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants have been identified for this gene although their full-length natures have not been determined.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Amyloid-beta induces a caspase-mediated cleavage of P2X4 to promote purinotoxicity. Varma R, et al. Neuromolecular Med, 2009. PMID 19562525.
Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells. Wareham K, et al. Br J Pharmacol, 2009 Aug. PMID 19552691.
Dynamic regulation of the P2X4 receptor in alveolar macrophages by phagocytosis and classical activation. Stokes L, et al. Eur J Immunol, 2009 Apr. PMID 19283779.
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