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Goat Anti-PAR6alpha / PARD6A Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-PAR6alpha / PARD6A Antibody AF1785a
    AF1785a (10 µg/ml) staining of paraffin embedded Human Pancreas. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.
  • IHC - Goat Anti-PAR6alpha / PARD6A Antibody AF1785a
    AF1785a (5 µg/ml) staining of paraffin embedded Human Heart. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NPB6
Other Accession NP_001032358, 50855
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 37388 Da
Additional Information
Gene ID 50855
Other Names Partitioning defective 6 homolog alpha, PAR-6, PAR-6 alpha, PAR-6A, PAR6C, Tax interaction protein 40, TIP-40, PARD6A, PAR6A
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-PAR6alpha / PARD6A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PAR6A
Function Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Cellular Location Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Note=Colocalizes with GTP- bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions
Tissue Location Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta
Research Areas
Citations (0)

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This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.


A role for the TGFbeta-Par6 polarity pathway in breast cancer progression. Viloria-Petit AM, et al. Proc Natl Acad Sci U S A, 2009 Aug 18. PMID 19667198.
Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. Justilien V, et al. Oncogene, 2009 Oct 15. PMID 19617897.
Regulation of planar cell polarity by Smurf ubiquitin ligases. Narimatsu M, et al. Cell, 2009 Apr 17. PMID 19379695.
The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. Nolan ME, et al. Cancer Res, 2008 Oct 15. PMID 18922891.
Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. Hartleben B, et al. J Biol Chem, 2008 Aug 22. PMID 18562307.

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$ 325.00
Cat# AF1785a
(40 western blots)
Availability: 7-10 days
Bulk Size
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