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PCSK9 AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1799a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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PCSK9 Antibody - Product info | |
| Other Accession | NP_777596 |
| Reactivity | Human |
| Concentration | 100ug/200ul |
| Isotype | IgG |
PCSK9 Antibody - Additional info | |
| Other Names PCSK9; FH3; NARC1; HCHOLA3; proprotein convertase subtilisin/kexin type 9; neural apoptosis regulated convertase 1; hypercholesterolemia, autosomal dominant 3; proprotein convertase subtilisin/kexin type 9; LDLCQ1; NARC-1 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions PCSK9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
PCSK9 Antibody - Application data
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AF1799a staining (0.2 µg/ml) of McA cell lysates: untransfected (1), transfected with wild type human pcsk9 (2), transfected with S127R human pcsk9 (3). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London.
PCSK9 Antibody - Related products
AP7333a: PCSK9 Antibody (N-term)
AP7333b: PCSK9 Antibody (C-term)
RI13860: PCSK9 predesign siRNA
BP7333a: PCSK9 Antibody (N-term) Blocking Peptide
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BACKGROUND
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
REFERENCES
Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients. Hu M, et al. Pharmacogenet Genomics, 2010 Oct. PMID 20679960. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014. Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses. Benn M, et al. J Am Coll Cardiol, 2010 Jun 22. PMID 20579540. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. Fontaine-Bisson B, et al. Diabetologia, 2010 Oct. PMID 20571754.
