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Goat Anti-PDE4D3 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-PDE4D3 Antibody AF1803a
    AF1803a (0.01 µg/ml) staining of Rat Brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q08499
Other Accession NP_006194.2, 5144, 24627 (mouse)
Reactivity Rat
Predicted Human, Pig
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 91115 Da
Additional Information
Gene ID 5144
Other Names cAMP-specific 3', 5'-cyclic phosphodiesterase 4D,, DPDE3, PDE43, PDE4D, DPDE3
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-PDE4D3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE4D
Synonyms DPDE3
Function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Cellular Location Apical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells.
Tissue Location Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Research Areas
Citations (0)

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This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.


Analyses of shared genetic factors between asthma and obesity in children. Mel茅n E, et al. J Allergy Clin Immunol, 2010 Sep. PMID 20816195.
[Phosphodiesterase 4D (PDE4D) gene polymorphism in patients with acute stroke from Moscow] . Genetika, 2010 Jun. PMID 20734779.
A genome-wide association study of neuroticism in a population-based sample. Calboli FC, et al. PLoS One, 2010 Jul 9. PMID 20634892.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Sex-differential genetic effect of phosphodiesterase 4D (PDE4D) on carotid atherosclerosis. Liao YC, et al. BMC Med Genet, 2010 Jun 12. PMID 20540798.

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$ 325.00
Cat# AF1803a
(40 western blots)
Availability: 7-10 days
Bulk Size
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