|Application ||WB, IHC, E|
|Other Accession||NP_002558, 5037, 23980 (mouse), 29542 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||21057 Da|
|Other Names||Phosphatidylethanolamine-binding protein 1, PEBP-1, HCNPpp, Neuropolypeptide h3, Prostatic-binding protein, Raf kinase inhibitor protein, RKIP, Hippocampal cholinergic neurostimulating peptide, HCNP, PEBP1, PBP, PEBP|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PEBP1 / RKIP (Internal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.|
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Provided below are standard protocols that you may find useful for product applications.
Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands. Shemon AN, et al. PLoS One, 2010 May 5. PMID 20463977.
RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex. Tang H, et al. FEBS Lett, 2010 Feb 19. PMID 20043910.
Reduction of Raf kinase inhibitor protein expression by Bcr-Abl contributes to chronic myelogenous leukemia proliferation. Takemura T, et al. J Biol Chem, 2010 Feb 26. PMID 20028985.
Raf kinase inhibitor protein enhances neuronal differentiation in human SH-SY5Y cells. Hellmann J, et al. Dev Neurosci, 2010 Mar. PMID 19955695.
Loss of RKIP expression is associated with poor survival in GISTs. Martinho O, et al. Virchows Arch, 2009 Sep. PMID 19705153.
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