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Goat Anti-Pescadillo Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Pescadillo Antibody AF1815a
    AF1815a (1 µg/ml) staining of Hela lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - Goat Anti-Pescadillo Antibody AF1815a
    AF1815a (3.8 µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00541
Other Accession NP_055118, 23481, 64934 (mouse)
Reactivity Human
Predicted Mouse, Pig, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 68003 Da
Additional Information
Gene ID 23481
Other Names Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028}, PES1 {ECO:0000255|HAMAP-Rule:MF_03028}
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Pescadillo Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PES1 {ECO:0000255|HAMAP-Rule:MF_03028}
Function Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Cellular Location Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli {ECO:0000255|HAMAP-Rule:MF_03028}
Tissue Location Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin
Research Areas
Citations (0)

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This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.


B23 interacts with PES1 and is involved in nucleolar localization of PES1. Zhang J, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Dec. PMID 20011973.
Down-regulation of pescadillo inhibits proliferation and tumorigenicity of breast cancer cells. Li J, et al. Cancer Sci, 2009 Dec. PMID 19764998.
Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. Rohrmoser M, et al. Mol Cell Biol, 2007 May. PMID 17353269.
Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex. Grimm T, et al. Nucleic Acids Res, 2006. PMID 16738141.

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$ 325.00
Cat# AF1815a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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