|Application ||WB, E|
|Other Accession||NP_001025062, 5223, 5224, 441531|
|Predicted||Mouse, Rat, Pig, Cow, Dog|
|Calculated MW||28804 Da|
|Other Names||Phosphoglycerate mutase 1, 184.108.40.206, 220.127.116.11, 18.104.22.168, BPG-dependent PGAM 1, Phosphoglycerate mutase isozyme B, PGAM-B, PGAM1, PGAMA|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PGAM1 / PGAM2 / PGAM4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 22.214.171.124 (synthase), but with a reduced activity.|
|Tissue Location||Expressed in the liver and brain. Not found in the muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
Manifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific phosphoglycerate mutase (PGAM-M) gene. Hadjigeorgiou GM, et al. Neuromuscul Disord, 1999 Oct. PMID 10545043.
The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency. Tsujino S, et al. Am J Hum Genet, 1993 Mar. PMID 8447317.
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