|Application ||WB, E|
|Other Accession||NP_006658, 10857, 53328 (mouse)|
|Calculated MW||21671 Da|
|Other Names||Membrane-associated progesterone receptor component 1, mPR, PGRMC1, HPR6.6, PGRMC|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PGRMC1 / MPR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for progesterone.|
|Cellular Location||Microsome membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein|
|Tissue Location||Widely expressed, with highest expression in liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney.
Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. Ahmed IS, et al. J Pharmacol Exp Ther, 2010 May. PMID 20164297. Progesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nude mice. Peluso JJ, et al. Endocrinology, 2009 Nov. PMID 19797399. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. Menon R, et al. Reprod Biol Endocrinol, 2009 Jun 15. PMID 19527514. Progesterone activates a progesterone receptor membrane component 1-dependent mechanism that promotes human granulosa/luteal cell survival but not progesterone secretion. Peluso JJ, et al. J Clin Endocrinol Metab, 2009 Jul. PMID 19417032. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. Velez DR, et al. Am J Obstet Gynecol, 2009 Feb. PMID 19019335.
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