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Goat Anti-PHR1 Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-PHR1 Antibody AF1823a
    AF1823a (1 µg/ml) staining of Rat Brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UF11
Other Accession NP_001123508, 58473, 27276 (mouse), 64471 (rat)
Reactivity Rat
Predicted Human, Mouse, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Additional Information
Other Names Pleckstrin homology domain-containing family B member 1, PH domain-containing family B member 1, Evectin-1, PH domain-containing protein in retina 1, PHRET1, Pleckstrin homology domain retinal protein 1, PLEKHB1, EVT1, KPL1, PHR1, PHRET1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-PHR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLEKHB1
Cellular Location Membrane. Cytoplasm {ECO:0000250|UniProtKB:Q9QYE9}. Note=Localizes to the apical juxta-nuclear Golgi region of the cytoplasm (By similarity). Membrane-associated (PubMed:10585447). Highly expressed in the outer segments of photoreceptor cells, both in rods and cones (PubMed:10585447). {ECO:0000250|UniProtKB:Q9QYE9, ECO:0000269|PubMed:10585447}
Tissue Location Highly expressed in retina and brain. Levels are very low or not detectable in all other tissues tested EMBL; U89715; AAF16675.1; -; mRNA EMBL; AF093249; AAF16684.1; -; mRNA EMBL; AF101054; AAF18572.1; -; mRNA EMBL; AF100612; AAF18932.1; -; mRNA EMBL; AF081583; AAF21786.1; -; mRNA EMBL; AK289620; BAF82309.1; -; mRNA EMBL; AK289909; BAF82598.1; -; mRNA EMBL; AK290109; BAF82798.1; -; mRNA EMBL; AK301299; BAH13452.1; -; mRNA EMBL; AK314748; BAG37288.1; -; mRNA EMBL; CH471076; EAW74900.1; -; Genomic_DNA EMBL; CH471076; EAW74903.1; -; Genomic_DNA EMBL; CH471076; EAW74904.1; -; Genomic_DNA EMBL; BC008075; AAH08075.1; -; mRNA CCDS; CCDS44672.1; -. [Q9UF11-1] CCDS; CCDS44673.1; -. [Q9UF11-2] CCDS; CCDS44674.1; -. [Q9UF11-3] CCDS; CCDS44675.1; -. [Q9UF11-4] RefSeq; NP_001123505.1; NM_001130033.1. [Q9UF11-2] RefSeq; NP_001123506.1; NM_001130034.1. [Q9UF11-3] RefSeq; NP_001123507.1; NM_001130035.1. [Q9UF11-4] RefSeq; NP_001123508.1; NM_001130036.1. [Q9UF11-4] RefSeq; NP_067023.1; NM_021200.2. [Q9UF11-1] RefSeq; XP_011543494.1; XM_011545192.2. [Q9UF11-3] RefSeq; XP_011543495.1; XM_011545193.2. [Q9UF11-4] UniGene; Hs.445489; - ProteinModelPortal; Q9UF11; - SMR; Q9UF11; - BioGrid; 121807; 7 IntAct; Q9UF11; 8 STRING; 9606.ENSP00000346127; - iPTMnet; Q9UF11; - PhosphoSitePlus; Q9UF11; - BioMuta; PLEKHB1; - DMDM; 48474683; - PaxDb; Q9UF11; - PeptideAtlas; Q9UF11; - PRIDE; Q9UF11; - ProteomicsDB; 84163; - ProteomicsDB; 84164; -. [Q9UF11-2] ProteomicsDB; 84165; -. [Q9UF11-3] ProteomicsDB; 84166; -. [Q9UF11-4] DNASU; 58473; - Ensembl; ENST00000227214; ENSP00000227214; ENSG00000021300. [Q9UF11-4] Ensembl; ENST00000354190; ENSP00000346127; ENSG00000021300. [Q9UF11-1] Ensembl; ENST00000398492; ENSP00000381505; ENSG00000021300. [Q9UF11-2] Ensembl; ENST00000398494; ENSP00000381507; ENSG00000021300. [Q9UF11-3] Ensembl; ENST00000535129; ENSP00000442616; ENSG00000021300. [Q9UF11-4] GeneID; 58473; - KEGG; hsa:58473; - UCSC; uc001oua.3; human. [Q9UF11-1] CTD; 58473; - DisGeNET; 58473; - EuPathDB; HostDB:ENSG00000021300.13; - GeneCards; PLEKHB1; - HGNC; HGNC:19079; PLEKHB1 MIM; 607651; gene neXtProt; NX_Q9UF11; - OpenTargets; ENSG00000021300; - PharmGKB; PA38787; - eggNOG; ENOG410IXBE; Eukaryota eggNOG; ENOG410Y287; LUCA GeneTree; ENSGT00390000013989; - HOVERGEN; HBG060487; - InParanoid; Q9UF11; - OMA; CYSAGAP; - OrthoDB; EOG091G14FB; - PhylomeDB; Q9UF11; - TreeFam; TF331787; - ChiTaRS; PLEKHB1; human GenomeRNAi; 58473; - PRO; PR:Q9UF11; - Proteomes; UP000005640; Chromosome 11 Bgee; ENSG00000021300; - CleanEx; HS_PLEKHB1; - ExpressionAtlas; Q9UF11; baseline and differential Genevisible; Q9UF11; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW GO; GO:0007602; P:phototransduction; NAS:UniProtKB GO; GO:0045595; P:regulation of cell differentiation; IBA:GO_Central Gene3D; 2.30.29.30; -; 1 InterPro; IPR011993; PH-like_dom_sf InterPro; IPR001849; PH_domain Pfam; PF00169; PH; 1 SMART; SM00233; PH; 1 PROSITE; PS50003; PH_DOMAIN; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Membrane; Reference proteome CHAIN 1 243 Pleckstrin homology domain-containing family B member 1 /FTId=PRO_0000053886 DOMAIN 21 128 PH. {ECO:0000255|PROSITE- ProRule:PRU00145} VAR_SEQ 1 19 Missing (in isoform 3 and isoform 4) /FTId=VSP_009779 VAR_SEQ 131 165 Missing (in isoform 2 and isoform 4) /FTId=VSP_009780 SEQUENCE 243 AA; 27186 MW; 8F60531721CF76CA CRC64; MSPAAPVPPD SALESPFEEM ALVRGGWLWR QSSILRRWKR NWFALWLDGT LGYYHDETAQ DEEDRVLIHF NVRDIKIGPE CHDVQPPEGR SRDGLLTVNL REGGRLHLCA ETKDDALAWK TALLEANSTP APAGATVPPR SRRVCSKVRC VTRSWSPCKV ERRIWVRVYS PYQDYYEVVP PNAHEATYVR SYYGPPYAGP GVTHVIVRED PCYSAGAPLA MGMLAGAATG AALGSLMWSP CWF
Research Areas
Citations (0)

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References

Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree. Lesch KP, et al. Mol Psychiatry, 2010 Mar 23. PMID 20308990.
PHR1 is a vesicle-bound protein abundantly expressed in mature olfactory neurons. Tan B, et al. Laryngoscope, 2010 May. PMID 20301200.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153.

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$ 335.00
Cat# AF1823a
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