|Application ||WB, E|
|Other Accession||NP_003653, 8544|
|Calculated MW||32113 Da|
|Other Names||Pirin, 184.108.40.206, Probable quercetin 2, 3-dioxygenase PIR, Probable quercetinase, PIR|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Pirin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).|
|Cellular Location||Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression|
|Tissue Location||Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level) Expressed in all tissues, with highest level of expression in heart and liver.|
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This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.
Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches. Licciulli S, et al. BMC Cell Biol, 2010 Jan 20. PMID 20089166.
Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. Licciulli S, et al. Leukemia, 2010 Feb. PMID 20010624.
Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese. Tang NL, et al. Bone, 2010 Feb. PMID 19766747.
Structural and biochemical analysis reveal pirins to possess quercetinase activity. Adams M, et al. J Biol Chem, 2005 Aug 5. PMID 15951572.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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