|Application ||WB, E|
|Other Accession||NP_000919, 5319, 18778 (mouse), 29526 (rat)|
|Calculated MW||16360 Da|
|Other Names||Phospholipase A2, 18.104.22.168, Group IB phospholipase A2, Phosphatidylcholine 2-acylhydrolase 1B, PLA2G1B, PLA2, PLA2A, PPLA2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PLA2G1B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PLA2, PLA2A, PPLA2|
|Function||PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.|
|Cellular Location||Secreted. Note=secreted from pancreatic acinar cells in its inactive form|
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Provided below are standard protocols that you may find useful for product applications.
Phospholipase A2 (EC 22.214.171.124) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]) .
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Structural insight into the activation mechanism of human pancreatic prophospholipase A2. Xu W, et al. J Biol Chem, 2009 Jun 12. PMID 19297324.
Regulation of Wnt/beta-catenin pathway by cPLA2alpha and PPARdelta. Han C, et al. J Cell Biochem, 2008 Oct 1. PMID 18636547.
The effects of beta2 adrenergic receptor gene polymorphism in lipid profiles. Kao WT, et al. Lipids Health Dis, 2008 May 21. PMID 18492292.
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