|Application ||WB, E|
|Other Accession||NP_065109, 57104|
|Predicted||Mouse, Rat, Cow|
|Calculated MW||55316 Da|
|Other Names||Patatin-like phospholipase domain-containing protein 2, 126.96.36.199, Adipose triglyceride lipase, Calcium-independent phospholipase A2, Desnutrin, IPLA2-zeta, Pigment epithelium-derived factor, TTS2.2, Transport-secretion protein 2, TTS2, PNPLA2, ATGL|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PNPLA2 / Desnutrin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.|
|Cellular Location||Lipid droplet. Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.
High frequency of ETFDH c.250G>A mutation in Taiwanese patients with late-onset lipid storage myopathy. Lan MY, et al. Clin Genet, 2010 Mar 29. PMID 20370797.
Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit. Johansen CT, et al. Int J Circumpolar Health, 2010 Feb. PMID 20167152.
Chronic TNFalpha and cAMP pre-treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and stimulated lipolysis. B茅zaire V, et al. FEBS Lett, 2009 Sep 17. PMID 19695247.
Characterization of desnutrin functional domains: critical residues for triacylglycerol hydrolysis in cultured cells. Duncan RE, et al. J Lipid Res, 2010 Feb. PMID 19692632.
Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes. Bezaire V, et al. J Biol Chem, 2009 Jul 3. PMID 19433586.
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