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Goat Anti-PTP4A1 / PRL-1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-PTP4A1 / PRL-1 Antibody AF1881a
    AF1881a (1 µg/ml) staining of A549 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q93096
Other Accession NP_003454, 7803
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 19815 Da
Additional Information
Gene ID 7803
Other Names Protein tyrosine phosphatase type IVA 1,, PTP(CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1, PTP4A1, PRL1, PTPCAAX1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-PTP4A1 / PRL-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTP4A1
Synonyms PRL1, PTPCAAX1
Function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
Cellular Location Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=And mitotic spindle
Tissue Location Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.
Research Areas
Citations (0)

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The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.


Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.
Enzyme activity of phosphatase of regenerating liver is controlled by the redox environment and its C-terminal residues. Skinner AL, et al. Biochemistry, 2009 May 26. PMID 19341304.
PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways. Luo Y, et al. Biochemistry, 2009 Mar 3. PMID 19199380.
New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53. Min SH, et al. Oncogene, 2009 Jan 29. PMID 18997816.
Expression of phosphatase of regenerating liver 1 and 3 mRNA in esophageal squamous cell carcinoma. Liu YQ, et al. Arch Pathol Lab Med, 2008 Aug. PMID 18684031.

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$ 325.00
Cat# AF1881a
(40 western blots)
Availability: 7-10 days
Bulk Size
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