|Application ||WB, E|
|Other Accession||NP_003454, 7803|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||19815 Da|
|Other Names||Protein tyrosine phosphatase type IVA 1, 22.214.171.124, PTP(CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1, PTP4A1, PRL1, PTPCAAX1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PTP4A1 / PRL-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.|
|Cellular Location||Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=And mitotic spindle|
|Tissue Location||Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.
Enzyme activity of phosphatase of regenerating liver is controlled by the redox environment and its C-terminal residues. Skinner AL, et al. Biochemistry, 2009 May 26. PMID 19341304.
PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways. Luo Y, et al. Biochemistry, 2009 Mar 3. PMID 19199380.
New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53. Min SH, et al. Oncogene, 2009 Jan 29. PMID 18997816.
Expression of phosphatase of regenerating liver 1 and 3 mRNA in esophageal squamous cell carcinoma. Liu YQ, et al. Arch Pathol Lab Med, 2008 Aug. PMID 18684031.
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