|Application ||WB, E|
|Other Accession||NP_996737, 9444, 19317 (mouse)|
|Predicted||Human, Rat, Pig, Dog, Cow|
|Calculated MW||37671 Da|
|Other Names||Protein quaking, Hqk, HqkI, QKI, HKQ|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Quaking / QKI Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients|
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Provided below are standard protocols that you may find useful for product applications.
QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998 [PubMed 9671495]). QKI proteins regulate RNA splicing, export of target RNAs from the nucleus, translation of proteins, and RNA stability (Lauriat et al., 2008 [PubMed 17918747]).
RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer. Yang G, et al. Gastroenterology, 2010 Jan. PMID 19686745.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder. Klempan TA, et al. Biol Psychiatry, 2009 Nov 1. PMID 19545858.
No association found between the promoter variations of QKI and schizophrenia in the Chinese population. Huang K, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2009 Feb 1. PMID 18938205.
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. Liu C, et al. Mol Med, 2008 Sep-Oct. PMID 18615156.
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