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Goat Anti-Quaking / QKI Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Quaking / QKI Antibody AF1890a
    AF1890a (0.3 µg/ml) staining of mouse brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96PU8
Other Accession NP_996737, 9444, 19317 (mouse)
Reactivity Mouse
Predicted Human, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 37671 Da
Additional Information
Gene ID 9444
Other Names Protein quaking, Hqk, HqkI, QKI, HKQ
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Quaking / QKI Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name QKI
Synonyms HKQ
Function RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
Cellular Location Nucleus. Cytoplasm
Tissue Location Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients
Research Areas
Citations (0)

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QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998 [PubMed 9671495]). QKI proteins regulate RNA splicing, export of target RNAs from the nucleus, translation of proteins, and RNA stability (Lauriat et al., 2008 [PubMed 17918747]).


RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer. Yang G, et al. Gastroenterology, 2010 Jan. PMID 19686745.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder. Klempan TA, et al. Biol Psychiatry, 2009 Nov 1. PMID 19545858.
No association found between the promoter variations of QKI and schizophrenia in the Chinese population. Huang K, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2009 Feb 1. PMID 18938205.
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. Liu C, et al. Mol Med, 2008 Sep-Oct. PMID 18615156.

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$ 325.00
Cat# AF1890a
(40 western blots)
Availability: 7-10 days
Bulk Size
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