|Other Accession||NP_002856, 5862, 59021 (mouse), 65158 (rat)|
|Predicted||Mouse, Rat, Pig, Cow|
|Calculated MW||23546 Da|
|Other Names||Ras-related protein Rab-2A, RAB2A, RAB2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-RAB2 / RAB2A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for protein transport from the endoplasmic reticulum to the Golgi complex.|
|Cellular Location||Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus membrane; Lipid-anchor Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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Provided below are standard protocols that you may find useful for product applications.
Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion.
Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders. Kim S, et al. Mol Psychiatry, 2010 Mar 23. PMID 20308991.
ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells. Buffa L, et al. Eur J Cell Biol, 2008 Apr. PMID 18187231.
Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases. Dong C, et al. Cell Signal, 2007 Nov. PMID 17716866.
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. Chi A, et al. J Proteome Res, 2006 Nov. PMID 17081065.
Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.
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