|Application ||WB, E|
|Other Accession||NP_002897, 5962, 19684 (mouse), 315655 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||68564 Da|
|Other Names||Radixin, RDX|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Radixin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively|
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Provided below are standard protocols that you may find useful for product applications.
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses.
Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. Parisiadou L, et al. J Neurosci, 2009 Nov 4. PMID 19890007.
Regulation of NK cell trafficking by CD81. Kr脌mer B, et al. Eur J Immunol, 2009 Dec. PMID 19830727.
Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study. Wolf C, et al. BMC Med Genet, 2009 Sep 15. PMID 19754948.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Belkina NV, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19255442.
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