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Goat Anti-RAPSN / Rapsyn Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-RAPSN / Rapsyn Antibody AF1912a
    AF1912a (0.5 µg/ml) staining of Human Skeletal Muscle lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13702
Other Accession NP_116034, 5913
Reactivity Human
Predicted Mouse, Rat
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 46328 Da
Additional Information
Gene ID 5913
Other Names 43 kDa receptor-associated protein of the synapse, RAPsyn, 43 kDa postsynaptic protein, Acetylcholine receptor-associated 43 kDa protein, RING finger protein 205, RAPSN, RNF205
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-RAPSN / Rapsyn Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RNF205
Function Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.
Cellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytoskeleton. Note=Cytoplasmic surface of postsynaptic membranes
Research Areas
Citations (0)

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This protein belongs to a family of proteins that are receptor associated proteins of the synapse. It contains a conserved cAMP-dependent protein kinase phosphorylation site. It is believed to play some role in anchoring or stabilizing the nicotinic acetylcholine receptor at synaptic sites. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Two splice variants have been identified for this gene.


Myasthenic syndrome due to defects in rapsyn: Clinical and molecular findings in 39 patients. Milone M, et al. Neurology, 2009 Jul 21. PMID 19620612.
Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear. Osman AA, et al. Mol Cell Neurosci, 2008 Jun. PMID 18420419.
Mutation analysis of CHRNA1, CHRNB1, CHRND, and RAPSN genes in multiple pterygium syndrome/fetal akinesia patients. Vogt J, et al. Am J Hum Genet, 2008 Jan. PMID 18179903.
Impaired receptor clustering in congenital myasthenic syndrome with novel RAPSN mutations. M脤ller JS, et al. Neurology, 2006 Oct 10. PMID 16931511.
Src-family kinases stabilize the neuromuscular synapse in vivo via protein interactions, phosphorylation, and cytoskeletal linkage of acetylcholine receptors. Sadasivam G, et al. J Neurosci, 2005 Nov 9. PMID 16280586.

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$ 325.00
Cat# AF1912a
(40 western blots)
Availability: 7-10 days
Bulk Size
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