|Application ||WB, E|
|Other Accession||NP_003466, 8045|
|Calculated MW||39945 Da|
|Other Names||Ras association domain-containing protein 7, HRAS1-related cluster protein 1, RASSF7, C11orf13, HRC1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-RASSF7 / HRAS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with gamma-tubulin|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. Recino A, et al. Biochem J, 2010 Sep 1. PMID 20629633.
Human longevity and 11p15.5: a study in 1321 centenarians. Lescai F, et al. Eur J Hum Genet, 2009 Nov. PMID 19367319.
RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis. Sherwood V, et al. Mol Biol Cell, 2008 Apr. PMID 18272789.
A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. Tsang HT, et al. Genomics, 2006 Sep. PMID 16730941.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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