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Goat Anti-RASSF7 / HRAS1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-RASSF7 / HRAS1 Antibody AF1917a
    AF1917a (1 µg/ml) staining of Jurkat cell lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q02833
Other Accession NP_003466, 8045
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 39945 Da
Additional Information
Gene ID 8045
Other Names Ras association domain-containing protein 7, HRAS1-related cluster protein 1, RASSF7, C11orf13, HRC1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-RASSF7 / HRAS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C11orf13, HRC1
Function Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with gamma-tubulin
Research Areas
Citations (0)

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Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. Recino A, et al. Biochem J, 2010 Sep 1. PMID 20629633.
Human longevity and 11p15.5: a study in 1321 centenarians. Lescai F, et al. Eur J Hum Genet, 2009 Nov. PMID 19367319.
RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis. Sherwood V, et al. Mol Biol Cell, 2008 Apr. PMID 18272789.
A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. Tsang HT, et al. Genomics, 2006 Sep. PMID 16730941.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

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$ 325.00
Cat# AF1917a
(40 western blots)
Availability: 7-10 days
Bulk Size
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