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Goat Anti-RBP4 (Internal) Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-RBP4 (Internal) Antibody AF1920a
    AF1920a (0.3 µg/ml) staining of Human Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P02753
Other Accession NP_006735, 5950, 19662 (mouse), 25703 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 23010 Da
Additional Information
Gene ID 5950
Other Names Retinol-binding protein 4, Plasma retinol-binding protein, PRBP, RBP, Plasma retinol-binding protein(1-182), Plasma retinol-binding protein(1-181), Plasma retinol-binding protein(1-179), Plasma retinol-binding protein(1-176), RBP4
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-RBP4 (Internal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RBP4
Function Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496).
Cellular Location Secreted
Tissue Location Detected in blood plasma and in urine (at protein level).
Research Areas
Citations (0)
citation

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Background

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.

References

[Expression and regulation of retinol binding protein 4 mRNA in human adipose tissue in obese and type 2 diabetics] Liu XH, et al. Zhonghua Yi Xue Za Zhi, 2010 May 11. PMID 20646597.
Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population. Nair AK, et al. PLoS One, 2010 Jul 6. PMID 20625434.
Decreased retinol binding protein 4 concentrations are associated with cholesterol gallstone disease. Wang SN, et al. J Formos Med Assoc, 2010 Jun. PMID 20610143.
Retinol-binding protein 4 levels in obese children and adolescents with glucose intolerance. Yeste D, et al. Horm Res Paediatr, 2010. PMID 20389103.
Association of plasma retinol-binding protein 4, adiponectin, and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients. Shim CY, et al. Yonsei Med J, 2010 May. PMID 20376890.

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$ 341.00
Cat# AF1920a
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