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Goat Anti-Restin / CLIP1 Antibody

Peptide-affinity purified goat antibody

     
  • IHC - Goat Anti-Restin / CLIP1 Antibody AF1922a
    AF1922a (2.5 µg/ml) staining of paraffin embedded Human Thyroid Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • WB - Goat Anti-Restin / CLIP1 Antibody AF1922a
    AF1922a (1 µg/ml) staining of Human Breast Cancer lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession P30622
Other Accession NP_937883, 6249, 56430 (mouse), 65201 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 162246 Da
Additional Information
Gene ID 6249
Other Names CAP-Gly domain-containing linker protein 1, Cytoplasmic linker protein 1, Cytoplasmic linker protein 170 alpha-2, CLIP-170, Reed-Sternberg intermediate filament-associated protein, Restin, CLIP1, CYLN1, RSN
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Restin / CLIP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLIP1
Synonyms CYLN1, RSN
Function Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity) Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698) {ECO:0000250|UniProtKB:Q922J3, ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17889670, ECO:0000269|PubMed:21646404}
Tissue Location Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.
Research Areas
Citations (0)

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References

Cdc2-mediated phosphorylation of CLIP-170 is essential for its inhibition of centrosome reduplication. Yang X, et al. J Biol Chem, 2009 Oct 16. PMID 19687009.
Microtubule plus-end tracking by CLIP-170 requires EB1. Dixit R, et al. Proc Natl Acad Sci U S A, 2009 Jan 13. PMID 19126680.
Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly. Tanenbaum ME, et al. EMBO J, 2008 Dec 17. PMID 19020519.
The membrane-tubulating potential of amphiphysin 2/BIN1 is dependent on the microtubule-binding cytoplasmic linker protein 170 (CLIP-170). Meunier B, et al. Eur J Cell Biol, 2009 Feb. PMID 19004523.
Lamellar bodies of human epidermis: proteomics characterization by high throughput mass spectrometry and possible involvement of CLIP-170 in their trafficking/secretion. Raymond AA, et al. Mol Cell Proteomics, 2008 Nov. PMID 18622020.

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$ 335.00
Cat# AF1922a
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