|Application ||WB, E|
|Other Accession||NP_658912, 6003|
|Calculated MW||19135 Da|
|Other Names||Regulator of G-protein signaling 13, RGS13, RGS13|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-RGS13 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)- alpha (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.
Genetic Variations in Regulator of G-Protein Signaling Genes as Susceptibility Loci for Second Primary Tumor/Recurrence in Head and Neck Squamous Cell Carcinoma. Wang J, et al. Carcinogenesis, 2010 Jul 12. PMID 20627871.
Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064.
RGS13 controls g protein-coupled receptor-evoked responses of human mast cells. Bansal G, et al. J Immunol, 2008 Dec 1. PMID 19017978.
The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.
RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. Han JI, et al. J Leukoc Biol, 2006 Jun. PMID 16565322.
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