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Goat Anti-RGS18 Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-RGS18 Antibody AF1926a
    AF1926a (1 µg/ml) staining of Human Peripheral Blood Mononucleocytes lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9NS28
Other Accession NP_570138, 64407
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Additional Information
Other Names Regulator of G-protein signaling 18, RGS18, RGS18, RGS13
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-RGS18 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS18
Synonyms RGS13
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha- 2, G(i) alpha-3 and G(q) alpha.
Cellular Location Cytoplasm.
Tissue Location Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver EMBL; AF076642; AAF80227.1; -; mRNA EMBL; AF268036; AAK58589.1; -; mRNA EMBL; AL596342; CAH71160.1; -; Genomic_DNA EMBL; AL513175; CAH71160.1; JOINED; Genomic_DNA EMBL; AK315377; BAG37770.1; -; mRNA EMBL; AL513175; CAH70529.1; -; Genomic_DNA EMBL; AL596342; CAH70529.1; JOINED; Genomic_DNA EMBL; CH471067; EAW91223.1; -; Genomic_DNA EMBL; BC020632; AAH20632.1; -; mRNA CCDS; CCDS1374.1; - RefSeq; NP_570138.1; NM_130782.2 UniGene; Hs.440890; - PDB; 2DLV; NMR; -; A=76-202 PDB; 2JM5; NMR; -; A=75-223 PDB; 2OWI; NMR; -; A=75-223 PDBsum; 2DLV; - PDBsum; 2JM5; - PDBsum; 2OWI; - ProteinModelPortal; Q9NS28; - SMR; Q9NS28; - BioGrid; 122160; 7 DIP; DIP-59096N; - IntAct; Q9NS28; 1 STRING; 9606.ENSP00000356430; - iPTMnet; Q9NS28; - PhosphoSitePlus; Q9NS28; - BioMuta; RGS18; - DMDM; 15214228; - OGP; Q9NS28; - EPD; Q9NS28; - PaxDb; Q9NS28; - PeptideAtlas; Q9NS28; - PRIDE; Q9NS28; - ProteomicsDB; 82475; - DNASU; 64407; - Ensembl; ENST00000367460; ENSP00000356430; ENSG00000150681 GeneID; 64407; - KEGG; hsa:64407; - UCSC; uc001gsg.4; human CTD; 64407; - DisGeNET; 64407; - EuPathDB; HostDB:ENSG00000150681.9; - GeneCards; RGS18; - HGNC; HGNC:14261; RGS18 HPA; HPA028727; - HPA; HPA045780; - MIM; 607192; gene neXtProt; NX_Q9NS28; - OpenTargets; ENSG00000150681; - PharmGKB; PA34369; - eggNOG; KOG3589; Eukaryota eggNOG; ENOG410YMJD; LUCA GeneTree; ENSGT00760000118903; - HOGENOM; HOG000233512; - HOVERGEN; HBG013233; - InParanoid; Q9NS28; - KO; K16449; - OMA; LMEQDSY; - OrthoDB; EOG091G0BDG; - PhylomeDB; Q9NS28; - TreeFam; TF315837; - Reactome; R-HSA-416476; G alpha (q) signalling events Reactome; R-HSA-418594; G alpha (i) signalling events EvolutionaryTrace; Q9NS28; - GeneWiki; RGS18; - GenomeRNAi; 64407; - PRO; PR:Q9NS28; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000150681; - CleanEx; HS_RGS13; - CleanEx; HS_RGS18; - Genevisible; Q9NS28; HS GO; GO:0005737; C:cytoplasm; IBA:GO_Central GO; GO:0005886; C:plasma membrane; IBA:GO_Central GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Ensembl GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:Ensembl Gene3D; 1.10.196.10; -; 2 InterPro; IPR016137; RGS InterPro; IPR034950; RGS18 InterPro; IPR036305; RGS_sf InterPro; IPR024066; RGS_subdom1/3 PANTHER; PTHR10845:SF155; PTHR10845:SF155; 1 Pfam; PF00615; RGS; 1 PRINTS; PR01301; RGSPROTEIN SMART; SM00315; RGS; 1 SUPFAM; SSF48097; SSF48097; 1 PROSITE; PS50132; RGS; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Signal transduction inhibitor CHAIN 1 235 Regulator of G-protein signaling 18 /FTId=PRO_0000204227 DOMAIN 86 202 RGS. {ECO:0000255|PROSITE- ProRule:PRU00171} MOD_RES 49 49 Phosphoserine MOD_RES 216 216 Phosphoserine {ECO:0000250|UniProtKB:Q99PG4} MOD_RES 218 218 Phosphoserine {ECO:0000250|UniProtKB:Q99PG4} CONFLICT 226 227 DV -> ML (in Ref. 2). HELIX 77 83 {ECO:0000244|PDB:2DLV} HELIX 87 92 {ECO:0000244|PDB:2DLV} HELIX 94 106 {ECO:0000244|PDB:2DLV} HELIX 111 122 {ECO:0000244|PDB:2DLV} HELIX 127 141 {ECO:0000244|PDB:2DLV} STRAND 144 147 {ECO:0000244|PDB:2DLV} HELIX 155 163 {ECO:0000244|PDB:2DLV} HELIX 164 166 {ECO:0000244|PDB:2DLV} TURN 170 173 {ECO:0000244|PDB:2DLV} HELIX 174 186 {ECO:0000244|PDB:2DLV} HELIX 188 193 {ECO:0000244|PDB:2DLV} HELIX 196 202 {ECO:0000244|PDB:2DLV} SEQUENCE 235 AA; 27582 MW; 973ABDE8EC7DE3D5 CRC64; METTLLFFSQ INMCESKEKT FFKLIHGSGK EETSKEAKIR AKEKRNRLSL LVQKPEFHED TRSSRSGHLA KETRVSPEEA VKWGESFDKL LSHRDGLEAF TRFLKTEFSE ENIEFWIACE DFKKSKGPQQ IHLKAKAIYE KFIQTDAPKE VNLDFHTKEV ITNSITQPTL HSFDAAQSRV YQLMEQDSYT RFLKSDIYLD LMEGRPQRPT NLRRRSRSFT CNEFQDVQSD VAIWL
Research Areas
Citations (0)

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Background

This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

References

Genetic Variations in Regulator of G-Protein Signaling Genes as Susceptibility Loci for Second Primary Tumor/Recurrence in Head and Neck Squamous Cell Carcinoma. Wang J, et al. Carcinogenesis, 2010 Jul 12. PMID 20627871.
Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Parkes M, et al. Nat Genet, 2007 Jul. PMID 17554261.
The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.

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$ 335.00
Cat# AF1926a
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